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Research Journal of Pharmacology and Pharmacodynamics
Year : 2018, Volume : 10, Issue : 1
First page : ( 17) Last page : ( 23)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2018.00004.6

Deeper insights into Mechanism Based Drug Action: A Review

Netam Ashish Kumar*, Prasad Jhakeshwar, Satapathy Trilochan

Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur-493111 Dist-Raipur (C.G.) India

*Corresponding Author E-mail: ashish.netam52@gmail.com

Online published on 24 May, 2018.

Abstract

Pharmacodynamic is considered as a major branch of pharmacology that deals with the study about the drug or ligand as well as its biochemical and physiological effects including their mechanisms of action on living organisms. Most of the drugs combine with some molecular structure on the surface of the cell or within the cell. This molecular structure is called a receptorwhich is made up of proteins or proteinaceous materials.When drug molecule approaches the receptors for binding and such post binding drug-receptor complex can altered configuration or charge distribution, and thereby triggers a catalytic effect leading to a response. Many drugs that may be exogenous or endogenous such as hormones or transmitters that mimic the effects because they combine with the receptors and produce its effect via different mechanism. In this review our efforts have been devoted to represent the different signal transduction pathways involved to elicit pharmacological response.

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Keywords

Receptor, Mechanism, Drug action, signal transduction pathways.

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