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Research Journal of Pharmacology and Pharmacodynamics
Year : 2018, Volume : 10, Issue : 1
First page : ( 1) Last page : ( 7)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2018.00001.0

Anti-Lithiatic Effect of Ipomoea batatas (L) Leaves and Tuberous Roots on Ethylene Glycol Induced Urolithiasis in Rats

Sathish R.*, Jeyabalan G.

Department of Pharmacy, Sunrise University, Alwar, Rajasthan, India

*Corresponding Author E-mail: rsvsathish2000@yahoo.co.in

Online published on 24 May, 2018.

Abstract

The present day medical management of lithiasis is either costly or not without side effects, hence the search for anti lithiatic drugs from natural sources has assumed greater importance. The anti-lithiatic activity of Ipomoea batatas leaves and tuberous roots at 200 and 400mg/kg doses in curative and preventive regimens were evaluated on ethylene glycol induced lithiasis in male wistar rats. Lithiasis was induced in rats by 0.75% ethylene glycolated water ad libitum for 28 days. On 28th day urinary excretion of calcium, oxalate, phosphate, uric acid and protein were significantly (p<0.01) decreased and magnesium excretion was significantly (p<0.01) increased in both curative and preventive regimens of I.batatas leaves and tuberous roots when compared with lithiatic control animals. The significant reduction (p<0.01) of serum creatinine, uric acid, blood urea nitrogen levels and significant increase (p<0.01) in creatinine clearance were also produced by I.batatas leaves and roots in both curative and preventive regimens. The I. batatas leaves and roots supplementation also caused significant (p<0.01) diuresis in rats accompanied by increased diuretic index. The maximum responses were produced by ethanolic extract of I.batatas tuberous roots and the effects were significantly (p<0.01) more than that of ethanolic extract of I.batatas leaves in both preventive and curative regimens. These observations concluded that the I.batatas roots (sweet potato) can be used as a herbal remedy in the treatment of lithiasis.

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Keywords

Anti-lithiatic, Diuretics, Ethylene glycol, Ipomoea batatas, Kidney stone, Sweet potato.

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