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Research Journal of Pharmacognosy and Phytochemistry
Year : 2017, Volume : 9, Issue : 3
First page : ( 182) Last page : ( 188)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2017.00034.6

Ethnopharmacological Story of Guggul Sterones: An Overview

Ghritlahare Suresh Kumar1,*, Satapathy Trilochan1, Panda Prasanna Kumar2, Mishra Geetanjali3

1Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhan Sabha, Raipur-493111, Dist-Raipur (C.G.) India.

2University Department of Pharmaceutical Sciences, Utkal University, Vanivihar, Bhubaneswar, Odisha-751004

3School of Pharmaceutical Education and Research, Berhampur University, Odisha-760007

*Corresponding Author E-mail: ghritlahare.suresh25@gmail.com

Online published on 17 October, 2017.

Abstract

Medicinal plants have played an important role throughout the world in treating and preventing human diseases, commiphora wightii is an important medicinal plant of herbal heritage of India. Guggul is obtained from commiphora mukul which belong to the Family, Burseraceae. C. mukul occurs in north east Africa, Somali and southern Arabia, in India it is found in Gujrat, Mysore, Bengal, M. Pradesh, Desert of Rajastasthan a list of few Commiphora species C. Mukul, C. Myrrh, C. Stocksiana Engl, C. Caudate Engl. etc, Guggul tree is small, 1.2–1.8 m high. Each plant yield about one kilogram of the product which is collected in cold Season, isolation of guggul sterons, extract with EtOAC yield soluble fraction and insoluble fraction, soluble fraction consist of 45% gum resin while 55% insoluble fraction contains carbohydrate, there is no any therapeutic property reported. Guggul lipid has active ingredients like Ketosteroids cis and trans is also known as sterones. guggulsterone-I, II, III, IV, V, VI, myrcene, dimyrcene, bioactive compounds in extract of mukul reported are dimyrcene, 15 α-camphorene. 16 linoleic, oleic, stearic, palmitic acid, sitosterol etc. It is therapeutically used in obesity hyperlipidaemia, arthritis, coronary thrombosis, cardiac disorders, diabetes, tumours, thyroid disorders, hepatic obstructions and weakness pharyngitis etc. Marketed formulation of Guggul triphala Guggul, Yougaraja Guggul, kaishora gugguln, Navaka guggul etc.

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Keywords

Commiphora mukul, Chemistry, Guggul lipid, Therapeutic uses.

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