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Research Journal of Pharmacognosy and Phytochemistry
Year : 2016, Volume : 8, Issue : 3
First page : ( 109) Last page : ( 115)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2016.00020.0

Evaluation of Anti-Oxidant and Hepatoprotective activity of Desmostachya bipinnata Leaf Extracts by Various Hepatotoxin Induced Albino Rat Models

Johnson D. Benito*, Charles Neethu. P., Mawlieh Banshongdor H, Passah Timai, Venkatanarayanan V.

Department of Pharmacology, RVS college of Pharmaceutical Sciences, Sulur, Coimbatore

*Corresponding Author E-mail: drbenitorvs@gmail.com

Online published on 18 October, 2016.

Abstract

Liver diseases are the major medical problems faced by the people all over the world. About 20, 000 deaths occur every year due to liver disorders Liver diseases are mainly caused by toxic chemicals, excessive intake of alcohol, infections and autoimmune disorders. Hepatotoxicity mainly implies chemical-driven liver damage. Certain drugs when taken in overdose and sometimes even when administered within therapeutic ranges may injure many organs. Some chemical agents including those that are used in laboratories (CCl4, paracetamol) and industries (Lead, arsenic) and natural chemicals (microcystine, aflatoxins) and herbal remedies (Cascara sagrada, Ephedra) can also cause hepatotoxicity Chemicals which cause liver injury are collectively known as hepatotoxins.

So the aim of this research is to evaluate anti-oxidant and hepatoprotective activity using Desmostachya bipinnata leaf extract because very less pharmacological studies have been carried out on the leaf of Desmostachya bipinnata by emphasizing on the antioxidant and hepatoprotective activity in Swiss albino rat model.

The whole plant materials are useful for the symptoms of different diseases. Desmostachya bippinata is indicated by several medicinal treatments for jaundice and other gastro intestinal disorder, Plant is a common weed plant mainly cultivated Northern parts of India.

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Keywords

Hepatoprotective, Anti oxidant, Desmostachya bipinnata.

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