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Research Journal of Pharmacognosy and Phytochemistry
Year : 2011, Volume : 3, Issue : 1
First page : ( 38) Last page : ( 40)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.

Effect of leave Extract of Prunus persica Linn on Acute Inflammation in Rats

Bhattacharjee Chiranjib1,*, Gupta Durgesh2, Deb Lokesh3, C Santhosh Kumar1, Debnath Subal1, Dutta A.S.4

1Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, India

2Rajiv Gandhi College of Pharmacy, Nautanwa, Maharajganj, UP– 273164, India

3I.B.S.D. Takyelpat, Imphal, Manipur, India

4R. K. Pharmacy College, Kasipur, Suri– Santhiaon, Azamgarh, UP– 276001, India

*Corresponding Author: Chiranjib Bhattacharjee Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 50227, Email: chiranjibcology@gmail.com, Phone: 08374131452

Online published on 21 March, 2013.

Abstract

Prunus persica Linn (L) widely distributed in Manipur, India. The leaves were used in folklore/traditional medicine to treat several inflammatory pathologies such as greenish swelling (gland), oedema etc. Reactive oxygen species as well as reactive free radicals such as hydroxyl (OH), nitric oxide (NO) etc. contribute significantly to these pathologies. In this study, antiinflammatory activity of the aqueous extracts (AEPp) of Prunus persica L leaves was evaluated on carrageenin induced oedema. The test sample at the dose of 200 mg/kg/p.o. were found to cause significant (***P<0.001) inhibition of carrageenin induced oedema. The test samples AEPp show the protection against inflammation less than standard diclofenac sodium 8mg/kg b.w. These observations established the anti-inflammatory effect of Prunus persica L leaves aqueous extract in acute inflammation.

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Keywords

Prunus persica, inflammation.

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