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Research Journal of Pharmacognosy and Phytochemistry
Year : 2020, Volume : 12, Issue : 2
First page : ( 114) Last page : ( 119)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2020.00020.5

Review on Antioxidant and Hepatoprotective activity of Medicinal plants against Paracetamol Induced animal model

Maharaja P1,*, Sengottuvel T1, Aarthi A2, Gopalasatheeskumar K3

1Department of Pharmacology, KMCH College of Pharmacy (The Tamil Nadu Dr. M. G. R. Medical University), Kovai Estate, Kalapatti Road, Coimbatore-641048, Tamil Nadu, India

2College of Pharmacy, MMC. Chennai

3Research Scholar, Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram-608002, Tamil Nadu, India

*Corresponding Author E-mail: maharaja0595@gmail.com

Online published on 10 August, 2020.

Abstract

Paracetamol is widely used analgesic and antipyretic which can lead to liver damage. Excessive and inappropriate use of paracetamol can lead to liver injury. Hepatotoxicity occurs due to drugs, steroids, vaccines, antiviral and other drugs. The hepatotoxic reactions by drugs are due to elevated ROS generation, oxidative stress and suppressed immune responses. The increase in the number of patients with liver dysfunction due to the overwhelming use of alcohol and drugs has paved the path for researchers and scientists to search for potential sources of new therapeutic agents for the prevention of drug -induced hepatotoxicity. Herbal drugs play a role in the management of various liver disorders most of them speed up the natural healing process of the liver. Many antioxidant agents have been studied in experimental and clinical studies to reduce or prevent acetaminophen-induced hepatotoxicity. An alternate view is that oxidative stress has a major role in hepatotoxicity. Antioxidants are agents that are capable of scavenging the free radicals by inhibiting oxidation, indirectly through iron chelation and quenching of triplet oxygen. The protective potential of medicinal plants could also be attributed to their phytoconstituent's ability to enhance the endogenous antioxidants. Hence there has been a great deal of interest recently in investigating the medicinal plants containing phenolic compounds that hold antioxidants.

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Keywords

Phytoconstituents, Catalase, GSH, SOD, ALT, AST.

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