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Research Journal of Pharmacognosy and Phytochemistry
Year : 2019, Volume : 11, Issue : 4
First page : ( 212) Last page : ( 216)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2019.00036.0

Investigation of In vitro Anti-cancer property of Adhatoda vasica in Hela, HepG2, MCF-7, MDAMB-231 Cell Lines

Nirmala Sankaradoss1,*, Sabapathi P Nadana2, Sudhakar M1, Bathula Naveen3, Sravanthi Y1

1Department of Pharmacognosy, Malla Reddy College of Pharmacy (Affiliated OU), Hyderabad-500014, Telangana, India

2Aizant Drug Research Solutions, Hyderabad-500100, Telangana, India

3School of Pharmaceutical Sciences, VISTAS, Chennai

*Corresponding Author E-mail: nirmala.cognosy@gmail.com

Online published on 31 December, 2019.

Abstract

The anticancer-cytotoxic activities of ethanolic extract of Adhatoda vasica were tested under in-vitro conditions in different cancer cell lines like MCF-7, MDAMB-231, Hela, HepG2 cell lines. The active constituents carbohydrates, steroids, Alkaloids, Tannins, Flavanoids, Saponins, gums and mucilage. The ethanolic extract of Adhatoda vasica showed a good cytotoxic activity (60%, 60%, 85% and 65%) in Hela, HepG2, MCF-7, MDAMB-231 cells at 24 hrs respectively. In this in-vitro studies the normal cells are act as a positive control. The ethanolic extract of Adhatoda vasica shows maximum percentage of 85% after 24 hrs. From this study, it can be concluded that the phytoconstituents of Adhatoda vasica have significant anticancer-cytotoxic activity on Hela, HepG2, MCF-7, MDAMB-231 cells.

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Keywords

Investigation of invitro anti-cancer property, Adhatoda vasica.

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