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Research Journal of Pharmacognosy and Phytochemistry
Year : 2018, Volume : 10, Issue : 4
First page : ( 299) Last page : ( 303)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2018.00048.1

Anti-Amnesic effect of methanolic extract of Tagetes erecta flower heads on Aluminium Induced Cognitive Impairment in Albino Mice

Dr. Raju M. Ganga*, Srilakshmi S

Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana State

*Corresponding Author E-mail: mgrpharma@gmail.com

Online published on 27 December, 2018.

Abstract

Objective

Anti-amnesic activity of methanolic extract of Tagetes erecta flower heads were carried out using various in-vitro and in-vivo models.

Methods

Preliminary Phytochemical screening of Tagetes erecta extract was carried out by using standard tests. Acute toxicity studies were performed as per OECD-425 guidelines. In-vivo anti-amnesic activity was evaluated in aluminium chloride induced amnesia (chronic) using Cook's pole climbing apparatus and elevated plus maze. Various biochemical parameters like anticholinesterase (AChE) using Ellman's assay and thiobarbituric acid reactive species (TBARS) were also estimated. Histopathological studies of brain were carried out in AlCl3 induced amnesic model.

Results

The acute toxicity studies revealed that the extract was safe upto 2000 mg/kg, bd.wt. The METE at two doses levels 200 and 400 mg/kg, bd. wt reversed the memory deficit induced by aluminium in mice models. METE significantly (p<0.05) reduced the brain AChE activity and TBARS level.

Conclusion

The presence of active constituents like flavonoids, terpenoids, steroids and phenols in methanolic extract of flower heads of Tagetes erecta might be responsible for its anti-amnesic and anti-cholinesterase activity.

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Keywords

Tagetes erecta, anti-amnesic, AChE inhibition, TBARS, aluminium chloride.

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