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Research Journal of Pharmacognosy and Phytochemistry
Year : 2018, Volume : 10, Issue : 1
First page : ( 1) Last page : ( 7)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2018.00001.8

Natural extracts and honey based impregnated gauze wound dressing preparation and in vitro antibacterial efficacy

Zam Wissam1,*, Harfouch Rim2, Ali Rand1, Atfah Yara1, Mousa Amena2

1Department of Analytical and Food Chemistry, Faculty of Pharmacy, Al-Andalus University for Medical Sciences, Tartous, Syrian Arab Republic

2Department of Microbiology, Faculty of Pharmacy, Al-Andalus University for Medical Sciences, Tartous, Syrian Arab Republic

*Corresponding Author E-mail: w.zam@au.edu.sy

Online published on 24 May, 2018.

Abstract

A wide range of wound dressings is commonly introduced to target different aspects of the wound healing process. The ideal dressing should maintain a rapid healing at low cost with minimal inconvenience to the patient. Pharmacological agents such as antibiotics, anti-inflammatory and other wound healing accelerators are added to dressings in order to improve the properties of wound dressings. Honey, pomegranate peels and olive leaves extracts are suitable natural products with a wide range of antibacterial and healing accelerator properties. Impregnated gauzes containing starch based mixtures of honey and aqueous extracts of olive leaves or pomegranate peels were prepared and their antibacterial efficacy was studied. Different prepared mixtures possess an antibacterial activity against both Pseudomonas aeruginosa and Staphylococcus aureus comparable to synthetic tested antibiotics. Impregnated gauze prepared using starch based mixtures of honey and pomegranate peel extract were more potent against S. aureus compared with impregnated gauze prepared using starch based mixtures of honey and olive leaves extract. The prepared impregnated gauze does not need a secondary dressing and can be cut to fit around the wound due to their flexible nature. Soft elastic property of impregnated gauze provides easy application and removal after wound is healed without any damage.

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Keywords

Impregnated gauze, Honey, Pomegranate peel aqueous extract, Olive leaves aqueous extract, Pseudomonas aeruginosaStaphylococcus aureus.

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