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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2017, Volume : 9, Issue : 4
First page : ( 183) Last page : ( 186)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2017.00030.1

Glimepiride Micro balloons: A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System

Shah Rutuja R., Shah Rutuja S., Vakhariya Rohan R.*

Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India

*Corresponding Author E-mail: rohanwakhariya@gmail.com

Online published on 24 May, 2018.

Abstract

Present research work was aimed to formulate and evaluate the gastro-retentive floating microballoons of glimepiride using hydrophilic polymers hydroxypropyl methylcellulose and Eudragit RS100 by emulsion solvent evaporation technique. The developed gastro retentive floating drug delivery system was evaluated for various parameters like micromeritic properties, buoyancy, in-vitro drug release, etc. It was observed that the drug delivery systems of glimepiride has shown excellent physicochemical properties, stability and controlled drug release pattern, by improving the bioavailability of the drug and also by managing the complicacy of the diabetes in a better manner.

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Keywords

Floating microspheres, Glimepiride, in-vitro drug release, solubility.

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