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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2017, Volume : 9, Issue : 4
First page : ( 168) Last page : ( 172)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2017.00027.1

Bicalutamide Tablets by Spray Dried Microspheres: An Approach to Enhance Solubility

Shah Rutuja R., Jadhav Abhijeet, Vakhariya Rohan R.*

Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India

*Corresponding Author E-mail: rohanwakhariya@gmail.com

Online published on 24 May, 2018.

Abstract

The aim of the present study was to enhance the dissolution rate of poorly water soluble drug, Bicalutamide. Bicalutamide is an antiandrogen agent used in the treatment of prostate cancer. To improve the dissolution rate of the drug, hydrophilic carriers like povidone K30 was and methanol was used for preparing microspheres. Microspheres of Bicalutamide were prepared by spray drying technique by using povidone K 30 at different concentrations. The microspheres were evaluated for drug release profile. The compatibility was studied by Fourier Transforms Infrared spectroscopy (FTIR). Prepared Microspheres were subjected to various physicochemical evaluations and in-vitro dissolution profile. The effects of different concentrations of polymer on Solubility enhancement were studied. The microspheres were compressed into tablets, and different tableting parameters were investigated. The dissolution profile of the tablets was also evaluated and compared with the marketed product. From the dissolution profile, it was observed that the carrier ratio of 3: 1 of magnesium aluminum silicate to povidone K 30 exhibited higher dissolution rate than the other formulations.

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Keywords

Solubility, Bicalutamide, Prostate cancer, microspheres, tablets.

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