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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2017, Volume : 9, Issue : 3
First page : ( 114) Last page : ( 122)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2017.00020.9

Controlled Porosity Osmotic Pump Tablets of Zidovudine and Lamivudine Combination: Optimization and Characterization

Sahoo Chinmaya Keshari1,*, Rao Surepalli Ram Mohan2, Sudhakar Muvvala3

1Ph. D Scholar, Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007

2Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia

3Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014

*Corresponding Author E-mail: sahoo.chinmaya83@gmail.com

Online published on 24 May, 2018.

Abstract

The present study was undertaken to develop controlled porosity osmotic pump tablets of zidovudine-lamivudine combination. The tablets were prepared by wet granulation method using HPMC E5LV, and osmogen was prinicipal ingredients a dose of 300mg zidovudine-150 mg lamivudine twice daily. The coating solution of core tablets were prepared by using cellulose acetate, poly ethylene glycol of different grades, sorbitol and acetone to quantity sufficient for different batches. The prepared tablets were evaluated for pre-compression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. Among developed formulations CS4 batch show 96.31% drug release in 8 h for zidovudine and 97.83% for lamivudine in 8 h. The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order, Higuchi, Korsmeyer Peppas and Hixon-Crowell model. The result of optimized formulation was independent of the pH and agitation intensity. Short term stability study (at 40±2ºC/75±5% RH for three months) on the best formulation indicated that there were no significant changes in thickness, friability, weight variation, drug content and in vitro drug release.

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Keywords

AIDS, Wet granulation, In vitro drug release, Stability study.

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