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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2017, Volume : 9, Issue : 2
First page : ( 48) Last page : ( 52)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2017.00010.6

Formulation and evaluation of sustained release matrix tablets containing aceclofenac and paracetamol

Khan Hamid1,*, Ali Javed2

1JK College of Pharmacy, Bilaspur, CG, India-495001

2Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi, India-110062

*Corresponding Author E-mail: khanhamid770@gmail.com

Online published on 22 September, 2017.

Abstract

The sustained release matrix tablets were formulated and evaluated by wet granulation method. Tablets were formulated using hydrophilic polymer and binder, HPMC K100 and PVP respectively. In-vitro drug release studies were carried out in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The amount of drugs released at different time intervals were determined by validated UPLC-PDA method. In-vitro drug release from prepared tablets showed better sustained release effect when compared with marketed combination tablets. Tablets thus formulated provided extended release of aceclofenac and paracetamol over the period of 6 h.

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Keywords

Aceclofenac, Paracetamol, Sustained Release, Matrix Tablets, HPMC.

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