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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2017, Volume : 9, Issue : 1
First page : ( 29) Last page : ( 32)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2017.00006.4

Influence of different beverages on disintegration behavior of pain reliever immediate release formulations

Rana Hardik B.*, Patel Kajol, Dholakia Mansi, Thakkar Vaishali T., Gohel Mukesh C., Gandhi Tejal R.

Department of Pharmaceutics, Anand Pharmacy College, Anand-388 001, Gujarat, India

*Corresponding Author E-mail: hardikrana1439@gmail.com

Online published on 26 April, 2017.


The objective of the present study was to assess the influence of different beverages like Coco-cola, Orange juice, butter milk, 6% fat and 5% fat containing milk on three immediate release pain reliever tablets of Nimesulide, Mefanamic acid and Aceclofenac. The study was performed in USP disintegration apparatus using different gastric simulated media at 37±0.5 ºC. A hybrid medium of different beverages (640 ml) with 0.1 N HCl (140 ml) was prepared to mimic in vivo condition. The result shown that disintegration time was increased in milk, buttermilk and orange juice and decreased in Coca cola compared to 0.1 N HCl. As the viscosity of fluid increses, the disintegration time was also increased. Coco-cola which contains Carbon Dioxide which was reduce the disintegration time of formulation. From the above study it can be concluded that there is variation in disintegration time of different formulations in different beverages. The patient on these medications should be advised against consuming different beverages with medications because it will affect bioavailability of mediation.



In vitro disintegration, Hybrid Media, Beverages, Pain reliever medications.


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