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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2017, Volume : 9, Issue : 1
First page : ( 19) Last page : ( 23)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2017.00004.0

Formulation and in-vitro evaluation of a sustained release matrix tablet of Telmisatan

Khan Hamid1,*, Ali Javed2

1Associate Professor, JK College of Pharmacy, Bilaspur, Chhattisgarh, India-495001

2Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi, India-110062

*Corresponding Author E-mail: khanhamid770@gmail.com

Online published on 26 April, 2017.

Abstract

The formulation and in-vitro evaluation of matrix tablets containing telmisartan as sustained release using low viscosity grade HPMC as the matrix forming hydrophilic polymer by wet granulation method. The tablets were subjected to in-vitro drug release study in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The drug released at various time intervals were determined by validated UPLC-PDA method. The prepared tablets showed better sustained release effect when compared with marketed tablets. The drug release mechanism from hydrophilic polymer was proposed. The formulated tablets provided sustained release of telmisartan over a period of 24 h.

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Keywords

Matrix tablet, Telmisartan, HPMC, Hydrophilic polymer, Sustained release.

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