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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2017, Volume : 9, Issue : 1
First page : ( 15) Last page : ( 18)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2017.00003.9

In vitro dissolution studies on commercial brands containing immediate release pioglitazone and metformin hydrochloride extended release tablets

Soumya K.*, Susanna S., Murthy T.E.G.K.

Dept. of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur, Andhra Pradesh, India

*Corresponding Author E-mail: KondaveetiSoumya@gmail.com

Online published on 26 April, 2017.

Abstract

The Quality control (QC) tests like weight variation, hardness, friability, drug content, and Invitro dissolution studies were performed for three commercially available brands containing the combination of two anti diabetic drug pioglitazone (15mg) and metformin (500mg) hydrochloride. The dissolution studies were performed in 0.1N hydrochloric acid (pioglitazone HCl) up to 45 minutes and in 6.8phosphate buffer (metformin HCl) up to 10hours. The selected formulations satisfied QC requirements. A significant difference in dissolution parameters were noticed from the above brands. The drug dissolution from pioglitazone and metformin hydrochloride marked brand followed first order kinetics and zero order kinetics respectively.

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Keywords

Pioglitazone Metformin combination comparative Invitro dissolution studies.

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