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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2016, Volume : 8, Issue : 4
First page : ( 273) Last page : ( 276)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2016.00038.0

Determination of Effect of pH, Temperature and RPM on dissolution of Telmisartan by Two Factorial Design

Nafees Sheema S*, Basha Sayad K, Thirumalesh S.B.

Department of Pharmaceutics, JNTUA-Oil Technological Research Institute, Ananthapuram, A.P., India

*Corresponding Author E-mail: sheemanafees5@gmail.com

Online published on 2 February, 2017.

Abstract

The main intend of present study was to determine how the dissolution parameters such as rpm, temperature and pH affects drug release for the marketed Telmisartan IR tablets. They were quantitatively and statistically studied by applying two factorial design. The dissolution parameters like temperature of the medium, pH of the medium and rpm were taken from low level to high levels and factorial design was applied at-1, +1 levels. The experiment was performed and drug release was estimated. Factorial design proved, the drug release up to 90% within 30 min. Finally, change in pH was found to be having more prominent effect on drug release than temperature and rpm.

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Keywords

Dissolution, Temperature, RPM, pH, Factorial Design.

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