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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2016, Volume : 8, Issue : 4
First page : ( 231) Last page : ( 236)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2016.00032.X

Evaluation Study of Sustained Release Ocular Insert of Brimonidine Tartrate and Timolol

Mujoriya R. Z.1,*, Dr. Kshirsagar M. D.2

1Research Scholar, P. Wadhawani College of Pharmacy, Yeotmal

2Professor, P. Wadhawani College of Pharmacy, Yeotmal

*Corresponding Author E-mail: raj_mujoriya@live.com

Online published on 2 February, 2017.

Abstract

The present work showed that incorporation of hydrophilic polymer into hydrophobic matrix system can be successfully done in order to model ocular inserts of Brimonidine Tartrate and Timolol providing promising controlled release delivery system. The control of IOP, systemic absorption and hence possible side effects using inserts was found to be better than conventional eye drops. Thus, on the basis of in-vivo anti-glaucoma activity, ocular safety test and stability studies, it can be concluded that this ocular insert can be a promising once-a-day controlled release formulation after due considerations of human in vivo studies.

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Keywords

Brimonidine Tartrate, Timolol, Hydrophilic Polymer, Hydrophilic Polymer, Controlled Release Delivery System, Anti-Glaucoma Activity, Ocular Safety Test, Stability Studies.

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