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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2016, Volume : 8, Issue : 3
First page : ( 190) Last page : ( 198)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2016.00026.4

Formulation Development and Evaluation of Floating Drug Delivery System for H2-Blocker Drug (Roxatidine Acetate)

Mujoriya Rajesh*, Mundhada Dharmendra, Pawar Sangram

Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra

*Corresponding Author E-mail: raj_mujoriya@live.com

Online published on 18 October, 2016.

Abstract

The present study has been a satisfactory attempt, to formulate and evaluate floating tablet of Roxatidine Acetate with a view of improving bioavailability and giving a controlled release of a drug. Floating tablet of Roxatidine Acetate will reduce the frequency of administration of drug and helps to minimize dose of drug and side effects associated with the drug. Roxatidine Acetate Floating Drug Delivery systems can be prepared by wet granulation method using HPMCK4M: Eudragit-RL100 polymer ratio and PVPK-30 as a binder, Sodium-bi-Carbonate: Citric acid as gas generating agent. The given floating tablet of Roxatidine Acetate was made to prepare with different polymer combination such as Eudragit-RL100: HPMCK4M and varying concentration of HPMCK4M, PVPK30. Comparing the all formulations, Floating drug delivery system formulation of F5 was considered as an ideal formulation which exhibited 99.26% of drug release in 8 hours, and floating lag time of 11seconds with a total floating time of 12 hours.

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Keywords

Floating tablet, bioavailability, controlled release, wet granulation method, floating lag time, total floating time.

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