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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2016, Volume : 8, Issue : 3
First page : ( 181) Last page : ( 189)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2016.00025.2

Formulation and Statistical optimisation of fast dissolving tablets of Ambroxol hydrochloride

Choudhury Priyanka*, Dr. Deb Pulak, Dr. Dash Suvakanta

Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara-17, Assam

*Corresponding Author E-mail: priyankachoudhury1812@gmail.com

Online published on 18 October, 2016.

Abstract

The aim of the present study is to formulate and optimize fast dissolving tablets of Ambroxol hydrochloride using a 23 response surface methodology employing Design Expert-10.0. Sodium starch glycolate and Camphor were selected as independent variables while disintegration time (sec) and water absorption ratio (%) were considered as responses. The prepared tablets were evaluated for various evaluation parameters including hardness, thickness, friability, drug content uniformity, wetting time, water absorption ratio and disintegration time. The prepared optimized fast dissolving tablets of Ambroxol hydrochloride having above 2 responsesdisintegration time(sec) and water absorption ratio of sec and %. The optimized batch having concentration of sodium starch glycolate and camphor was found within the standard limit of parameters-disintegration time (sec) and water absorption ratio(%). The direct compression method in this study is relatively simple and safe and a stable, effective and pleasant tasting fast dissolving tablets, which has a good balance over disintegration time and water absorption ratio, was formulated.

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Keywords

Ambroxol Hydrochloride, Sodium starch glycolate, Camphor, Statistical optimization.

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