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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2015, Volume : 7, Issue : 3
First page : ( 193) Last page : ( 198)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2015.00029.4

Formulation and In-Vitro Evaluation of In-lay Matrix Tablets Containing Telmisartan and Hydrochlorothiazide

Khan Hamid1,*, Ali Mushir2, Ahuja Alka2, Ali Javed2

1JK College of Pharmacy, Bilaspur, Chhattisgarh, India-495001

2Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India-110062

*Address for correspondence: Dr. Hamid Khan, Associate Professor, JK College of Pharmacy, Bilaspur, CG, India-495001, E-mail: hamid_khan008@yahoo.co.in

Online published on 29 October, 2015.

Abstract

The aim of the presented work was formulation and in-vitro evaluation of in-lay tablets containing telmisartan as sustained release outer core and hydrochlorothiazide as immediate release inner core using HPMC and copolymer carbopol 71G. Tablets were evaluated via various quality control tests and in-vitro drug release studies. Drug release study was carried out hydrochloric acid buffer of pH 1.2 (0.1N) using USP paddle apparatus. The validated HPLC-UV method was applied to determine the amount of drugs released at different time intervals. The mechanism of drug release through polymeric network was established. Prepared tablets showed extended sustain release of telmisartan over a period of 20 h and hydrochlorothiazide as immediate release within 30 min.

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Keywords

In-lay tablet, telmisartan, hydrochlorothiazide, sustained release, immediate release.

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