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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2015, Volume : 7, Issue : 2
First page : ( 125) Last page : ( 128)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2015.00018.X

Wound Healing Activity of Poly Herbal formulation

Ghori Syed Safiullah1*,**, Gouse Mohammed2, Panda Niranjan3, Khaled Shaik1, Basheeruddin Syed1, Baig Mirza Danish1, Yaqub Mohammed1, Mufaqqum Mohammed1, Nazneen Arfa1, Butul Amtul Zehra1

1Pharmacology Research Lab, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad-50001, Telangana, India

2Almocare Herbal and Ayurvedic Clinic, Chirag Ali lane, Abids, Hyderabad, Telangana, India

3Department of Pharmaceutics, Anwarululoom College of Pharmacy, New Mallepally, Hyderabad-50001, Telangana, India

*Corresponding Author E-mail: safiullahghori@gmail.com

**Address for correspondence: Syed Safiullah Ghori Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad- 500001 Telangana, India

Online published on 25 June, 2015.

Abstract

Aim

To evaluate the Wound healing potential of a Poly herbal formulation.

Material and Methods

In the present work a poly herbal Unani formulation; beeswax (base), sesame oil (10%), olive oil (10%), honey (20%), psoraleac (5%), borax (10%), arnica (5%) and curcuma longa (1%) were used and the wound healing potential was determined by both excision and incision wound healing models. Albino wistar rats were used for this purpose. The wound area in excision wound model and tensile strength in incision wound model were determined. Histopathological studies were also carried out to determine the phases of wound healing.

Results

From the results obtained it was evident that the PUF has shown wound healing activity in both excision and incision wound models. In the EWM the beneficial effect of the PUF was evident from the day of first measurement as the progressive decrease in wound area was observed. On the 2nd day of wounding, the wound area shrinkage in 10% formulation treated group was more when compared to the other test groups. The wound area was decreasing constantly and predominantly in all test treated groups as compared to the negative control group. In the IWM there was decrease in tensile strength of the animals treated with the 10% formulation and was comparable with the standard group. In the histopathological examination, the phases in the wound healing process were observed and it showed that proliferation phase was the predominant stage of action of PUF. The best re-modeling, particularly, re-epithelization were detected with the 10% formulation group On the other hand; faster keratinization characterized with minor intraepithelial cornification was seen in 15% group.

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Keywords

Poly herbal Unani formulation (PUF), Excision wound model (EWM), Incision wound model (IWM).

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