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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2015, Volume : 7, Issue : 2
First page : ( 93) Last page : ( 97)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2015.00013.0

Design Development of Liquisolid Compacts of Atorvastatin Calcium

Krishna A. Navya*,**, Deepthi Y., Aruna S., Murthy T E G K

Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), A.P.-522101, India

*Corresponding Author E-mail: bcpbtl@sancharnet.in

**Address for correspondence: A. Navya Krishna, Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), A.P, pin-522101, India

Online published on 25 June, 2015.

Abstract

The present work is to formulate and evaluate liquisolid compacts of Atorvastatin calcium. Atorvastatin calcium is an anti hyperlipedmic drug belongs to class of statins. The bioavailability is 14% due to dissolution rate limitation and its biological half life is 14 hours. The solubility of Atorvastatin was enhanced by liquid solid compact technology. So the aim of this work is to increase the solubility and in-vitro dissolution of practically insoluble drug Atorvastatin, liquisolid tablet consists of lactose (flowlac), cab-o-sill and PG as liquid vehicle. The prepared formulations were evaluated for drug content, weight variation, hardness, friability, disintegration, dissolution. The better drug release was observed from the F8 formulation (1:5) containing (flowlac) Atorvastatin 20 mg, carrier 505.65 mg, coating material 10mg, and super disintegrating and lubricants 11.64, 23.45 were added. The selected formulation was evaluated for stability studies.

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Keywords

Atorvastatin calcium, liquisolid compacts, carrier, coating material, in-vitro dissolution, bioavailability.

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