(3.230.1.126)
Users online: 1576    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2015, Volume : 7, Issue : 1
First page : ( 69) Last page : ( 73)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2015.00010.5

Influence of Casting Solvent and Polymer on Permeability of Propranolol Hydrochloride Through Eudragit RL100 and Eudragit RLPO Films

Soujanya B.1,*, Geethanjali J.2, Mounika D.3, Saikishore V.4

1Research Scholar, Bapatla College of Pharmacy, Bapatla

2Department of Analysis, Bapatla College of Pharmacy, Bapatla

3Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla

4Associate Professor, Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, India

Address for correspondence: B. Soujanya Research Scholar, Bapatla College of Pharmacy, Bapatla

*Corresponding Author E-mail: sowji2818@gmail.com

Online published on 17 March, 2015.

Abstract

In the present work, eudragit L100 and Eudragit RLPO films were prepared and evaluated as rate controlling membrane for transdermal drug delivery systems. Dibutyl phthalate or propylene glycol at a concentration of 15w/w of the polymer was used as a plasticizer in the preparation of eudragit L100 and Eudragit RLPO films. Casting on mercury surface technique was employed for preparation of eudragit L100 and Eudragit RLPO films. The dry films were evaluated for physical appearance, water vapour transmission, drug diffusion and permeability coefficient. Both water vapour transmissions, drug diffusion rate followed zero-order kinetics. The mechanism of drug release was governed by peppas model. The diffusion exponent of release profiles (slope) has a value of 1.056–1.071 (n>1), which indicates super case ∐ transport diffusion. The results obtained in the present study thus indicate that the polymer and solvents used in the preparation of films have shown significant influence on the water vapour transmission, drug diffusion and permeability of the films.

Top

Keywords

Polymer, solvents, water vapour transmission, drug diffusion and permeability coefficient.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
452,192,736 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.