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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2015, Volume : 7, Issue : 1
First page : ( 44) Last page : ( 50)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2015.00007.5

Design and Evaluation of Meloxicam Mouth Dissolving Tablets

Rao K Sreenivasa1,*, Khan Maajid1, Udgirkar Dattatraya1, Patil Praveen S1, Biradar Karnakumar V2

1Department of Pharmaceutics, RRKS College of Pharmacy, Bidar-585402, India

2Department of Pharmacology, RRKS College of Pharmacy, Bidar-585402, India

Address for correspondence: K Sreenivasa Rao, Department of Pharmaceutics, RRKS College of Pharmacy, Bidar-585402, India

*Corresponding Author E-mail: bidarkaran@gmail.com

Online published on 17 March, 2015.

Abstract

In the present study, Mouth dissolving tablets of Meloxicam were designed with a view to enhance patient compliance. Meloxicam, a new non-steroidal anti-inflammatory agent mainly used for the treatment of osteoarthritis and rheumatoid arthritis. However, it may cause gastro-intestinal tract disturbances/induce ulcer to avoid these complications we designed Mouth dissolving tablets of Meloxicam. The prepared batches of Mouth dissolving tablets were evaluated for hardness and friability, drug dispersion time, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time (approximately 8–30 s), all formulations were tested for in vitro drug release pattern (in Phosphate buffer), Short-term stability (40°C/75% RH for 3 months) and drug-excipient interaction study (IR spectroscopy). Among all the formulations, the formulation prepared by 6% sodium starch glycolate was found to have minimum dispersion time (8.77 s) and Short-term stability studies on the promising formulation indicated that there were no significant changes in drug content and in vitro dispersion time.

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Keywords

Mouth dissolving tablets (MDT), Novel drug delivery systems (NDDS) Meloxicam, Sodium Starch Glycolate, Croscarmellose sodium.

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