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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2015, Volume : 7, Issue : 1
First page : ( 15) Last page : ( 20)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2015.00004.X

Design, Development and Optimization Aceclofenac Effervescence tablets by Central Composite Design

Mavani Prakash B., Patel Grishma M.*, Shukla Arun K., Shelat Pragna K.

K. B. Institute of Pharmaceutical Education & Research, Gandhinagar, Gujarat, India

Address for correspondence: Grishma M. Patel, K. B. Institute of Pharmaceutical Education & Research, Gandhinagar, Gujarat, India.

*Corresponding Author E-mail: grishma1284@yahoo.co.in

Online published on 17 March, 2015.

Abstract

The oral solid dosage forms are the most popular way of taking medication despite having some disadvantages like slow absorption and hence prolong onset of action. These problems can be overcome by some drug delivery system like mouth dissolving tablets, dispersible tablets, effervescent tablets, etc. Aceclofenac is often used to relieve the inflammation, swelling, stiffness and joint pain which sometimes required fast onset of action. Aceclofenac effervescent tablet was prepared to enhance onset of action. Tablets were prepared using anhydrous citric acid, tartaric acid and effersoda as effervescent components by direct compression method. Solid dispersion of Aceclofenac with anhydrous lactose can be prepared to increase solubility of aceclofenac. The solid dispersions were evaluated for drug content, practical yield, solubility and DSC for drug complex study. Central composite design was used for optimization of aceclofenac effervescent tablet. The effervescent formulations were evaluated for physicochemical parameters, drug content, effervescent lag time, total effervescent time, in vitro drug release study, FTIR for compatibility and stability testing. Optimized formula showed more than 50% drug release after 5 min and hence faster onset of action. The study point of aceclofenac effervescent tablet is ease of administration, accuracy of dosing and faster onset of action.

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Keywords

Aceclofenac, effervescent tablet, central composite design, solid dispersion.

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