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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2015, Volume : 7, Issue : 1
First page : ( 11) Last page : ( 14)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2015.00003.8

Antihyperlipidemic Effect of Polyherbal Formulation (PHF) in High Fat Diet Induced Hyperlipidemia

Mahurkar Nitin1, Sayeed ul hasan S.M.2,*, Quadri S. Mutaal

1Department of Pharmacology, HKES's College of Pharmacy, Gulbarga, Karnataka, India

2Department of Pharmacology, MAK College of Pharmacy, Moinabad, Andhra Pradesh, India

Address for correspondence: S.M Sayeed ul hasan, Department of Pharmacology, MAK College of Pharmacy, Moinabad, Andhra Pradesh, India

*Corresponding Author E-mail: sayeedhasan1986@gmail.com

Online published on 17 March, 2015.

Abstract

The present study was undertaken to design and assess the influence of polyherbal formulation (PHF) on lipid profile in hyperlipidemic rats. The chronic hyperlipidemia was induced in wistar albino rats of either sex using high fat diet i.e. mixture of coconut oil and vanaspati ghee (2:3 v/v). The rats were fed with high fat diet for a period of 08 consecutive weeks. After the treatment with PHF, the following biochemical parameters were evaluated -serum total cholesterol, triglycerides, low density lipo-protein cholesterol (LDL), very low density lipo-protein cholesterol (VLDL) and serum high density lipo-protein cholesterol (HDL). The treatment with PHF (100 and 200mg/kg, p.o.) significantly reduced the hyperlipidemia, by decreasing the levels of total serum cholesterol, LDL, VLDL and by increasing the HDL in a dose dependent manner, when compared to the control vehicle and standard drug Atorvastatin. The results demonstrated that the PHF possess significant antihyperlipidemic activity.

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Keywords

Hyperlipidemia, High fat diet, Polyherbal formulation.

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