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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2013, Volume : 5, Issue : 6
First page : ( 315) Last page : ( 319)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.

Antioxidant and Free Radical Scavenging Activity Azima tetracantha lam

Muthukumaran P.*, Abirami C.,  Priyatharsini

P.G Department of Biochemistry, Meenakshi Chandrasekaran Arts and Science College, Karambayam, Pattukkottai-614 626, Thanjavur, Tamilnadu, India

*Corresponding Author: Muthukumaran P., P.G Department of Biochemistry, Meenakshi Chandrasekaran Arts and Science College, Karambayam, Pattukkottai 614 626, Thanjavur, Tamilnadu, India kumaran.bio82@yahoo.com

Online published on 3 February, 2014.

Abstract

Antioxidants play an important role in inhibiting and scavenging free radicals, thus providing protection to human against infections and degenerative diseases. Current research is now directed towards natural antioxidants originated from plants due to safe therapeutics. Azima tetracantha Lam is used in Indian traditional medicine for a wide range of various ailments. To understand the mechanism of pharmacological actions, antioxidant properties of the Azima tetracantha Lam leaves extract were tested using standard in vitro models. The ethanolic extract of Azima tetracantha Lam exhibited strong scavenging effect on superoxide, nitric oxide radical and reducing power radical scavenging assay. The free radical scavenging effect of Azima tetracantha Lam extract was comparable with that of the reference antioxidants. The data obtained in the present study suggests that the extract of Azima tetracantha Lam leaves have potent antioxidant activity against free radicals, prevent oxidative damage to major biomolecules and afford significant protection against oxidative damage.

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Keywords

Azima tetracantha Lam, Antioxidant, Ethanolic extract.

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