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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2020, Volume : 12, Issue : 3
First page : ( 150) Last page : ( 154)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2020.00025.7

Formulation and In-vitro Evaluation of Buccal Tablets of Hydralazine HCl

Dr Reddy Y. Krishna*, Shirisha P.

Department of Industrial Pharmacy, Nalanda College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana

*Corresponding Author E-mail: rajinisuralabs1@gmail.com

Online published on 10 August, 2020.

Abstract

Hydralazine HCL is a medication used to treat high blood pressure and heart failure. This includes high blood pressure in pregnancy and very high blood pressure resulting in symptoms. The mucoadhesive buccal tablets of Hydralazine HCL were papered by direct compression method using natural and synthetic polymer like Pectin, Sodium alginate and Carbopol. The compatibility studies of drug and excipient were performed by FT-IR spectroscopy. After examining the flow properties of the powder blends the results were found to be within prescribed limits and indicated good flowing property, hence it was subjected to compression. The tablets were evaluated for post-compression parameters like weight variation, hardness, thickness, friability, drug content uniformity, surface pH, in-vitro studies like Moisture absorption and drug release. Formulation (H2) containing Pectin showed exhibited optimum drug release (99.32%). Surface pH was found to be range of salivary pH. All the evaluation parameters given the positive result and comply with the standards.

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Keywords

Hydralazine HCL, Pectin, Sodium alginate, Carbopol and Buccal tablets.

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