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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2020, Volume : 12, Issue : 2
First page : ( 93) Last page : ( 97)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2020.00017.8

Development and Evaluation of Gastroretentive Floating Tablets of Nizatidine based on Effervescent Technology

Dr. Reddy Y. Krishna*, Tahseen Faria

Department of Pharmaceutics, Nalanda College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana

*Corresponding Author E-mail: rajinisuralabs1@gmail.com

Online published on 10 August, 2020.

Abstract

In the present research work gastro retentive floating matrix formulation of Nizatidine by using various polymers were developed. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimised. Then the formulation was developed by using different concentrations of polymers Amla extract, Ginger extract, Fenugreek extract, Isapgol husk as polymeric substances. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations Amla extract as polymer were retarded the drug release more than12 hours (F3=98.73%). whereas in low concentrations the polymer was unable to produce the desired action. The optimised formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed peppas release kinetics mechanism of drug release.

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Keywords

Nizatidine, Amla extract, Ginger extract, Fenugreek extract, Isapgol husk, Floating Tablets.

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