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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2020, Volume : 12, Issue : 2
First page : ( 78) Last page : ( 82)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2020.00014.2

Formulation and In Vitro Evaluation of Fast Dissolving Tablets of Rosuvastatin Calcium using Direct Compression Method

Dr. Reddy Y. Krishna*, Begum Samrin

Department of Pharmaceutics, Nalanda College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana

*Corresponding Author E-mail: rajinisuralabs1@gmail.com

Online published on 10 August, 2020.

Abstract

Mouth dissolving tablet is an innovative solid unit dosage form that overcome the problem of swallowing and provide rapid disintegration and dissolution to release the drug as soon as they come in contact with saliva, hence provide quick onset action. The aim of this study was to formulate and evaluate mouth dissolving tablets of Rosuvastatin Calcium using super disintegrating agent. Rosuvastatin Calcium is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. Mouth dissolving tablets were prepared by direct compression method using super disintegrating agents (Banana Powder, Primojel and Sodium starch glycolate). Prepared tablet were evaluated for Hardness, weight variation, friability, thickness, disintegration and dissolution study. According to results of optimized batches it has been concluded that Formulation batch R4 was an ideal batch which contain 64mg concentration of Banana Powder showed least disintegration time that is 13seconds and maximum drug release of (99.31%) within 30 minutes and was best among all the formulations.

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Keywords

Rosuvastatin Calcium, Banana Powder, Primojel, Sodium starch glycolate, Fast Dissolving tablets, direct compression method, formulations and super disintegrating agents.

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