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Formulation of PEG-based Solid Dispersion for Dissolution rate Enhancement of Modafinil Vyas Jigar*, Daxini Kapil, Vyas Puja Sigma Institute of Pharmacy, Vadodara, Gujarat, 390019 *Corresponding Author E-mail: drjigarvyas@gmail.com
Online published on 10 August, 2020. Abstract Solid dispersions of modafinil were prepared using polyethyleneglycols, in various proportions by melting, solvent evaporation and simple mixing method. Based on the solubility and melting point study, PEG 8000 was selected and solid dispersion batch F9 containing drug: PEG 8000 in 1:4 was formulated as tablet (batch TF9) and evaluated for in-vitro drug dissolution and six month stability. The results were compared with that of tablet containing physical mixture of drug: PEG 8000 in the same ratio (batch TF27) and conventional tablet containing plain modafinil (batch CT). Tablet TF9 has shown significant improvement of dissolution profile of modafinil when compared with that of tablet TF27 and CT. Present study conclusively demonstrated that PEG 8000 enhanced water solubility of modafinil by amorphisation, which was confirmed by XRPD, FTIR, SEM and DSC. The melting method was found better than solvent evaporation method for enhancement of dissolution profile. Top Keywords Modafinil, Solubility enhancement solid dispersion, Polyethyleneglycols. Top | |
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