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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2019, Volume : 11, Issue : 4
First page : ( 280) Last page : ( 287)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2019.00047.8

A Review on Mucoadhesive Drug Delivery Systems

Kumar A.M. Sateesh*, Bharath N., Rao M. Durga Srinivasa, Venkatesh P., Hepcykalarani D., Prema R.

Jagan's Institute of Pharmaceutical Sciences, Jangalakandriga (v)-524 326, Muthukur (M), Nellore (Dist.), Andhra Pradesh, India

*Corresponding Author E-mail: amsateeshpharma@gmail.com

Online published on 3 February, 2020.

Abstract

This article gives a brief idea about Bioadhesive drug delivery systems based on hydrogels to biological surfaces that are covered by mucus. Bioadhesion is an interfacial phenomenon in which two materials, at least one of which is biological are held together by means of interfacial forces, when the associated biological system is mucous. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. Oral mucoadhesive micro carriers were having potentiality for controlling and extending release profile so as to improve performance and patient compliance. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.

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Keywords

Drug Delivery, micro carrier, mucoadhesion, bioadhesion and oral hydrogels.

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