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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2019, Volume : 11, Issue : 4
First page : ( 275) Last page : ( 279)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2019.00046.6

Healing effect of Spray gel collagen extract from Channa striata bone on burn in rats

Rachmasari Amallia*, Kartini Rafidha Aisyah**, Alviani Gita***, Solihah Indah****

Department of Pharmacy, Sriwijaya University, Inderalaya, 30662, South Sumatera, Indonesia

*Corresponding Author E-mail: amalliarachmasari@gmail.com

**rafidhaaisyah@gmail.com

***gitaalviani99@gmail.com

****indahsolihah@mipa.unsri.ac.id

Online published on 3 February, 2020.

Abstract

The aims of this study was to investigate the healing effect of spray gel collagen extract from Channa striata wastes bones in a deep second-degree burn model in rats. Collagen extraction was used acid soluble collagen (ASC) method. Spray gel collagen extract was used Carbopol® 940 and HPMC-60SH as gelling agent. The quality control of spray gel collagen extract was evaluated for physical appearance, adhesive strength, pH, viscosity, pump delivery, and spray pattern. The in vivo study was used 24 adults, male Wistar-albino rats, divided into 4 groups. The first was normal saline (NS) groups as negative control. The second was base spray gel (BSG) group as placebo. The third was Bioplacenton® group as positive control. And the last was spray gel collagen extract (SCE) group as treatment group. The percentage of wound contraction was observed every 2 days for 14 days, followed by observation in the period of epithelialization of the wound. Collagen extraction with ASC method has 1.927, 14±4, 76 ppm of total protein. The results of quality control of SCE meets all standard value for gel preparation. Furthermore, the result of in vivo study showed that SCE group has the best rate of burn wound healing among all control groups, and significantly better than NS and BSG groups. In conclusion, application of SCE is effective in healing burn-related skin wounds in the rat model as well as Bioplacenton® gel.

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Keywords

Channa striata, collagen, spray gel, burn wound, rat.

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