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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2019, Volume : 11, Issue : 3
First page : ( 181) Last page : ( 185)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2019.00032.6

Nephroprotective Effect of Luteolin against Gentamicin-induced Nephrooxicity in Albino Rats

Kashyap Seema1,*, Sao Malti1, Sharma Harish2, Yadav Amrendra Pratap1, Kori Maohan Lal1

1Sri Sathya Sai Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India

2Shri Shankarcharya Group of Institutes, Faculty of Pharmaceutical Sciences, Junwani, Bhilai, CG, India

*Corresponding Author E-mail: kashyapseema85@gmail.com

Online published on 31 December, 2019.

Abstract

Currently, edible plants are found to have biological and pharmacological activities and are used in various domains. The gravity of the impact of renal failure on human health is well known and as there is no specific tretment for renal failure, the current study was undertaken to evaluate the effect of luteolin. The experiment was done in gentamycin-induced acute renal failure in Wistar albino rats. Twenty four rats were divided into four groups. Luteolin was given and 24 h urine output, serum creatinine and serum proteins were measured for all the groups. Kidneyswere examined for histopathological changes. The nephroprotective activity of the luteolin was tested and it showed significant improvement in biochemical parameters and histopathological change.

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Keywords

Nephrotoxicity, Nephroprotective, Luteolin, Gentamycin.

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