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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2019, Volume : 11, Issue : 3
First page : ( 169) Last page : ( 172)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2019.00029.6

Formulation and Evaluation of Propranolol HCl Floating Tablets-A Gastro Retentive Drug Delivery

Banik Kabita*, Dr. Phalguna Y, Sangeetha B

Bharat Institute of Technology, (BIT), Manganpally, Hyderabad, India

*Corresponding Author E-mail: banikkabita64@gmail.com

Online published on 31 December, 2019.

Abstract

The objective of present study was to develop a gastroretentive drug delivery system of propranolol hydrochloride. The biggest problem in oral drug delivery is low and erratic drug bioavailability. This study” shown the formulation of floating tablets of Propranolol HCl by employing carbopol and HPMC as polymers. One of the disadvantages in using propranolol is extensive first pass metabolism of drug and only 25% reaches systemic circulation. The bioavailability of propranolol increases in presence of food. Also, the absorption of various drugs such as propranolol through P-glycoprotein (P-gp) efflux transporter is low and erratic. The density of P-gp increases toward the distal part of the gastrointestinal tract (GIT). Therefore, it was decided to formulate floating tablet of propranolol so that it remains in the upper part of GIT for longer time. The prepared tablets were evaluated among all the formulations (P1-P5). Formulations were evaluated for floating lag time, duration of floating, dimensional stability, drug content and in vitro drug release profile. It was observed that formulation”-5 has shown better buoyancy and dissolution profile.

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Keywords

Bioadhesive Floating Matrix, Propranolol Hcl, ACE, Gastroretentive drug delivery, Floting lag time.

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