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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2019, Volume : 11, Issue : 3
First page : ( 164) Last page : ( 168)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2019.00028.4

Formulation and Evaluation of Mucoadhesive Buccal Tablets of Captopril

Begum SK Asha1,*, Sura Ramya Sri2, Phanindra B.1, Kumar P. Pavan1, Chandrasekhar1, Naveen1, Reshma1

1Nimra College Pharmacy, Ibrahimpatnam, Vijayawada, Krishna District, Andhra Pradesh-521456

2Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana, India

*Corresponding Author E-mail: rajinisuralabs1@gmail.com

Online published on 31 December, 2019.

Abstract

The objective of this study was to develop effective mucoadhesive buccal tablets of Captopril. Tablets of Captopril were prepared by direct compression method using bioadhesive polymers like Acritamer 940, Manugel, Hypromellose K100. Buccal tablets were prepared by taking polymers in different ratios. Buccal tablets were evaluated by different parameters such as thickness, hardness, weight uniformity, content uniformity studies. The tablets were evaluated for in vitro release in pH 6.8 phosphate buffer for 8 hr in standard dissolution apparatus. In order to determine the mode of release, the data was subjected to Zero order, first order, Higuchi, Korsmeyer and Peppas diffusion model. The formulation F2 showed maximum drug release (98.56%) in 8 hrs. Captopril mucoadhesive tablets for buccal delivery could be prepared with required in-vitro release properties.

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Keywords

Captopril, Buccal tablets, Acritamer 940, Manugel, Hypromellose K100, in vitro drug release.

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