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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2018, Volume : 10, Issue : 4
First page : ( 272) Last page : ( 278)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2018.00040.X

Linezolid Loaded Biodegradable Polymeric Nanoparticles Formulation and Characterization

Shaji Jessy*, Kumbhar Monika

Department of Pharmaceutics, Prin. K. M. Kundnani College, of Pharmacy, Cuffe Parade, Colaba, Mumbai. 400005

*Corresponding Author E-mail: jessy.shaji@gmail.com

Online published on 27 December, 2018.

Abstract

After HIV, Tuberculosis(TB) is the second lethal disease on the globe. In this present study, double emulsion solvent evaporation method was used to formulate Linezolid loaded biodegradable PLGA polymeric nanoparticles (LZD-PNPs). Poly[D, L-Lactic-co-glycolic acid] 50: 50 was used as a biodegradable polymer, Tween 80 as a non-ionic surfactant and PVA was used as a co-polymer or stabilizer. Design-expert® v.11.0.5.0 software was used for optimization of LZD-PNPs. Particle size distribution and entrapment efficiency were the main two factors considered for optimization of LZD loaded polymeric formulation. Preformulation studies and characterization of the optimized batch were carried out by Fourier Transfer Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM) analysis. The mean particle size of LZD loaded PNPs optimized batch was found to be at 75nm with ±22 SD and was monodispersed. Entrapment efficiency of optimised batch was calculated by indirect method & found to be 87.64%. Physicochemical Stability of LZD loaded PNPs formulations were confirmed by zeta potential analysis and was found to be-32mv which indicates stability of the formulation.In vitro drug release study was carried out using dialysis bag method. The cumulative percentage drug releasewas found to be 92.34±1.37 for 24 hours. SEM studies revealed that formulated LZD polymeric nanoparticle have spherical morphology, smooth texture, and LZD was successfully coated by Biodegradable PLGA polymer.

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Keywords

TB, Double Emulsion Solvent Evaporation, Biodegradable PLGA, Polymeric Nanoparticle, LZD-PNPs.

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