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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2018, Volume : 10, Issue : 4
First page : ( 245) Last page : ( 252)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2018.00036.8

Recent trends in role of superdisintegrants to formulation of solid oral dosage form

Bhowmik Debjit1,*, Bhanot Rishab1, Kumar K.P. Sampath2

1Himachal Institute of Pharmaceutical Education and Research, Nadaun, Hamirpur, H.P

2Department of Pharmacy, Coimbatore Government Medical College, Coimbatore

*Corresponding Author E-mail: debjit_cr@yahoo.com

Online published on 27 December, 2018.

Abstract

Disintegrating agents are substances routinely included in the tablet formulations to aid in the break up of the compacted mass when it is put into a fluid environment. They promote moisture penetration and dispersion of the tablet matrix. In recent years, several newer agents have been developed known as “Superdisintegrants”. These newer substances are more effective at lower concentrations with greater disintegrating efficiency and mechanical strength. On contact with water the superdisintegrants swell, hydrate, change volume or form and produce a disruptive change in the tablet. Effective superdisintegrants provide improved compressibility, compatibility and have no negative impact on the mechanical strength of formulations containing high-dose drugs. The orally disintegrating tablet is a solid dosage form that disintegrates and dissolves in the mouth without the need of water within 60 seconds or less. According to the US Food and Drug Administration, orally disintegrating tablet is "a solid dosage form containing medicinal substances, which disintegrates rapidly, usually within a matter of seconds, when placed upon the tongue" By FDA guidance, orally disintegrating tablet should have an in vitro disintegration time of 30 seconds or less, based on the US Pharmacopeia disintegration test method.

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Keywords

Superdisintegrants, Solid oral dosage form.

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