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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2018, Volume : 10, Issue : 3
First page : ( 175) Last page : ( 178)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2018.00027.7

Method Development and Validation of Indomethacin in Bulk Drug and Capsule Formulation by using Mix Hydrotrophy

Rathod Swati B.*, Salunke Poonam A., Kulkarni Vaishali C., Chavhan Bhavika R., Dr. Barhate Shashikant D.

Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner–424206

*Corresponding Author E-mail: srathod251@gmail.com

Online published on 31 October, 2018.

Abstract

New, simple and rapid method indicating UV-Visible spectroscopy was developed and validated for the estimation of Indomethacin in pure form, and in formulation. Mix hydrotropic solution was used as a solvent. The adequate drug solubility and maximum assay sensitivity (320 nm) in the wavelength range of (200–400 nm), the linear calibration curve was obeyed in the con(Y=0.015X-0.002), and correlation Coefficient (R2=0.998). This determination of Indomethacin capsules form, no interference was found from capsule excipients at the selected wavelength and analysis conditions. It was concluded that the developed method is accurate, sensitive, precise, and reproducible and indirectly for the estimation of Indomethacin content in pharmaceutical formulation.

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Keywords

UV Spectroscopy, Indomethacin, urea), Analytical validation.

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