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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2018, Volume : 10, Issue : 3
First page : ( 169) Last page : ( 174)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2018.00026.5

Formulation and Evaluation of Fast Dissolving Tablets of Cefdinir by Employing Solid Dispersion

Banerjee Janmajoy, Padmalatha H., Ramesh Korra, Chanda Ranabir*

Gyana Jyothi College of Pharmacy, Uppal Bus Deptt, Hyderabad, India

*Corresponding Author E-mail: ranabirchanda@gmail.com

Online published on 31 October, 2018.

Abstract

Cefdinir is a third-generation oral cephalosporin antibiotic that is, characterized by low solubility and high permeability therefore, the enhancement of its solubility and dissolution profile is expected to significantly improve its bioavailability and reduce its side effects. In our present study we prepared different batches of Cefdinir using polyplasdone and croscarmellose sodium. The pre-compression blend of cefdinir soild dispersions were characterized with respect to angle of repose, bulk density, tapped density, Carr's index and Hausner's ratio. The pre compression blends of all the batches were showed good to fair flowability and compressibility. The formulated tablets were evaluated for various quality control parameters. The tablets were passed all the tests. Among all the formulations F6 formulation showed good drug release that is 96.45% in 20 minutes. Hence from the dissolution data it was evident that F6 formulation is the optimized formulation.

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Keywords

Cefdinir, PEG 4000, Mannitol, Polyplasdone XL, Croscarmellose sodium, Solid dispersion.

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