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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2018, Volume : 10, Issue : 2
First page : ( 109) Last page : ( 113)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2018.00017.4

Enzyme Immobilization: A Bridge of Understanding between Biotechnology and Pharmacy

Nair Nisha, Thakur Amrita, Agrawal Mukta, Thakur Juhi, Gupta Shubhangi, Sahu Bharti, kumar Devendra, Rai Indu, Sonkar Jaya, Sahu Kalyani,  Kuldeep, Kumar Kailash,  Muktanand, Kaushik Nidhi, Sahu Omkar, Sahu Somsunder, Kumar Umesh, Tripathi D. K.,  Ajazuddin, Alexander Amit*

Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, India, 490024

*Corresponding Author E-mail: itsmeamitalex@gmail.com

Online published on 7 July, 2018.

Abstract

As the demands of world biotechnology and pharmaceutical industries have increased, a need to develop and enhance, reaction stability, reusability and shelf life of enzymes has also become necessary. Hence noveltechnologies are needed to facilitate large-scale and economic formulations. Enzyme immobilization is a technique most apt to meet all the challenges in regards to enzyme activity. It provides immensescope for increasing availability of enzyme to the substrate and also increases product turn over, also increases the efficiency of an enzyme to a great extent. Immobilization of enzyme can be done by entrapment, support binding, cross-linking of enzyme crystals, etc. For immobilization, numerous natural and synthetic support materials are used. Nowadays, immobilized enzymes are much more preferred rather than their free counterpart because of their prolonged availability. Immobilized enzymesare widely used in pharmaceutical industries, cosmetic industries, food processing, biofuel production and many other sectors. The present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the current subject.

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Keywords

Immobilization, adsorption, cross-linking, microencapsulation, covalent bonding.

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