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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2018, Volume : 10, Issue : 2
First page : ( 95) Last page : ( 102)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2018.00015.0

Self Microemulsifying Drug Delivery System (SMEDDS): A Novel Approach to Improve the Therapeutic Efficacy of Orally Administered Drug

Kanoujia Kritika, Dewangan Chandraprabha, Masih Ayushi, Sinha Dipti, Oraon Divya, Jaiswal Manisha, Sahu Monika, Kumari Ranjeeta, Pradhan Sapna, Suman Ravi, Dewangan Rajkishan, Banjare Roman, Paikra Pradeep, Rawtiya Mukesh, Agrawal Mukta,  Ajazuddin, Tripathi D. K., Alexander Amit*

Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, India, 490024

*Corresponding Author E-mail: itsmeamitalex@gmail.com

Online published on 7 July, 2018.

Abstract

The oral route is most preferred one as there is ease of administration and it is a painless approach. This favored route is restricted to those drug molecules that are absorbent over gastric mucosa. One of the promising techniques is SMEDDS. Self-micro emulsifying drug delivery system has gained more attention due to enhanced oral bioavailability enabling a reduction in dose, more consistent temporal profiles of drug absorption, selective targeting of drug towards specific absorption window in GIT, and protection of drugs from the unreceptive environment in the gut. SMEDDS provide the dissolved drugs form, and also its small size of droplets imparts substantial interfacial area for the absorption of drugs. It can simply get penetrated into the GIT which is the major advantages over another emulsion. The present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject

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Keywords

SMEDDS, oral drug delivery, GIT, solubility, bioavailability.

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