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Pesticide Research Journal
Year : 2019, Volume : 31, Issue : 2
First page : ( 172) Last page : ( 178)
Print ISSN : 0970-6763. Online ISSN : 2249-524X.
Article DOI : 10.5958/2249-524X.2019.00029.3

Profenofos Induced Oxidation Stress and Genotoxicity in Female Albino Rats

Brar Sukhmanpreet Kaur*, Khera Kuldeep Singh

Department of Zoology, Punjab Agricultural University, Ludhiana, 141004, Punjab, India

*Corresponding author E-mail: bsukhman51@gmail.com

Online published on 8 January, 2020.

Abstract

Organophosphates (OPs) have been shown to induce oxidative stress (OS) by elevating levels of reactive oxygen species and genotoxic effects by the irreversible damage to the various organs. Present study reports the toxic effects of profenofos on female albino rats at two sub-chronic doses of 1/10th and 1/50th of LD50, administered for six weeks each. Activity levels of antioxidative enzymes viz: catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and lipid peroxidation (LPO) were differentially altered in liver, kidneys and ovaries of profenofos treated rats as compared to control. The total antioxidant activity (AOA) was also significantly decreased in the plasma of profenofos treated rats. Increased frequencies of micronucleated polychromatic erythrocytes in bone marrow cells of treated rats also indicated the genotoxic effect of profenofos. The results infer that profenofos induces oxidative stress and genotoxicity in female albino rats in a dose dependent manner.

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Keywords

Profenofos, oxidative stress, genotoxicity, catalase, lipid peroxidation.

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