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Open Journal of Psychiatry & Allied Sciences
Year : 2018, Volume : 9, Issue : 2
First page : ( 161) Last page : ( 163)
Print ISSN : 2394-2053. Online ISSN : 2394-2061.
Article DOI : 10.5958/2394-2061.2018.00019.8

Isoniazid associated psychosis: case series from a tertiary care centre

Singh Hemendra1, Devi HJ Gayathri2,*, Chabaria Mamatha3, Shekar Kartik3

1Assistant Professor, Department of Psychiatry, M.S. Ramaiah Medical College, Bangalore, Karnataka, India

2Associate Professor, Department of Respiratory Medicine, M.S. Ramaiah Medical College, Bangalore, Karnataka, India

3Intern, Department of Psychiatry, M.S. Ramaiah Medical College, Bangalore, Karnataka, India

*Correspondence Dr. Gayathri Devi HJ, MBBS, DTCD, MD (Chest), FCCP, Professor & HOD, Respiratory Medicine, M.S. Ramaiah Medical College, Consultant Pulmonologist, M.S. Ramaiah Memorial Hospital, Bangalore-560054, Karnataka, India. gayathrijoshy@gmail.com

Online published on 18 July, 2018.

Abstract

Isoniazid (INH) is a commonly used first line antitubercular drug. INH associated psychosis is a rare psychiatric manifestation. We report two cases of pulmonary tuberculosis, where the patients developed psychosis after being given a therapeutic dose of INH. In vulnerable patients, INH may cause change in concentration of neurotransmitters by inhibition of monoamine oxidase (MAO) and deficiency of pyridoxine. This might precipitate psychosis. Our observation also supports the hypothesis that INH associated psychotic disorders might have a pathophysiological substrate in common with some schizophrenia patients, who show remarkable response to low doses of atypical antipsychotic agents and pyridoxine supplementation.

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Keywords

Antitubercular Agents. Antipsychotic Agents. Pyridoxine.

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