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Open Journal of Psychiatry & Allied Sciences
Year : 2019, Volume : 10, Issue : 1
First page : ( 32) Last page : ( 36)
Print ISSN : 2394-2053. Online ISSN : 2394-2061.
Article DOI : 10.5958/2394-2061.2019.00009.0

Wilson's disease: a cognitive neuropsychological perspective

Ghosh Doyel1, Mukhopadhyay Pritha2,*, Roy Prasanta Kumar3, Biswas Atanu4

1MPhil, Clinical Psychologist, Department of Clinical Psychology, Institute of Psychiatry, Kolkata, West Bengal, India

2PhD, Professor, Department of Psychology, University of Calcutta, 92 APC Road, Kolkata, West Bengal, India

3MPhil, Assistant Professor, Department of Clinical Psychology, Institute of Psychiatry, Kolkata, West Bengal, India

4DM, Associate Professor of Neurology, Bangur Institute of Neurosciences (BIN), Kolkata, West Bengal, India

*Correspondence Prof. Pritha Mukhopadhyay, Department of Psychology, University College of Science, Technology & Agriculture (UCSTA), 92 APC Road, Kolkata-700009, West Bengal, India. prithamukhopadhyay@gmail.com

Online published on 16 January, 2019.

Abstract

Background

Wilson's disease manifests as neuro-psychological or psychiatric symptoms along with neurological and liver disease. The present study aimed to probe into the declarative and non-declarative memory profile of Wilson's disease patients from a neurocognitive perspective.

Methods

The study involved a sample of 12 Wilson's disease patients and 12 matched non-patient individuals who were assessed on Global Assessment Scale for Wilson's disease, the Edinburgh handedness inventory, memory scales from PGI Battery of Brain Dysfunction, Rey Auditory Verbal Learning Test, and mirror tracing task.

Results

The overall result indicated that the Wilson's disease patient group differed with their non-patient counterparts with respect to immediate memory, recall, recognition, semantic memory, and procedural learning.

Conclusion

The neural substrates related to the neuro-psychological symptoms of Wilson's disease patients are found to be a neural network involving basal ganglia, fronto-striatal circuits, and cerebellar region.

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Keywords

Psychiatry, Liver Disease, Memory, Neural Substrates.

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