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Medicinal Plants - International Journal of Phytomedicines and Related Industries
Year : 2016, Volume : 8, Issue : 3
First page : ( 260) Last page : ( 265)
Print ISSN : 0975-4261. Online ISSN : 0975-6892.
Article DOI : 10.5958/0975-6892.2016.00022.8

Anti-inflammatory activity of Melochia corchorifolia

Talluri Mallikarjuna Rao1,*, Rao Battu Ganga2, Rao Y.Venkateswaea1

1Department of Botany, Andhra University, College of Science and Technology, Andhra University, Visakhapatnam, Andhra Pradesh, India

2Pharmacognosy and Phytochemistry, AU College of Pharmacy, Andhra University, Visakhapatnam, Andhra Pradesh, India

*Corresponding author e-mail: tmrao1987@gmail.com

Online published on 9 November, 2016.

Abstract

The present study was carried out to assess Anti-inflammatory activity of Melochia corchorifolia extracts (Methanol, Hydroalcoholic, Ethyl acetate and Hexane) using carrageenan-induced rat paw edema model and the results were compared with standard drug Indomethacin. The selected plant extracts significantly inhibited inflammation of paw edema along with the standard drug, Indomethacin. Of all extracts, methanol extract posses’ significant activity compared to other extracts reducing paw edema inflammation on carrageenan induced rats. The methanol extract at a dose of 500 mg/kg showed more percentage inhibition i.e. 53.47±2.19. From the results of the study, it may it may conclude that M. corchorifolia possess bioactive molecule which are responsible for reduction of inflammations individually or in combination. Further studies are needed for isolation and characterization of bioactive molecules from M. corchorifolia.

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Keywords

Melochia corchorifolia, anti-inflammatory activity, indomethacin, carrageenin, paw edema.

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