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Medicinal Plants - International Journal of Phytomedicines and Related Industries
Year : 2011, Volume : 3, Issue : 1
First page : ( 9) Last page : ( 13)
Print ISSN : 0975-4261. Online ISSN : 0975-6892.
Article DOI : 10.5958/j.0975-4261.3.1.015

In vitro anticancer and antimalarial Erystagallin-A from Erythrina variegata (L.) stem bark

Herlina Tati1,*,  Nurlelasari1, Kurnia Dikdik1, Supratman Unang1, Udin Zalinar2

1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, West Java, Indonesia

2Research Centre for Chemistry, Indonesian Institute of Sciences, Bandung 40135, West Java, Indonesia

*Corresponding author: Tati Herlina E-mail: tatat_04her@yahoo.com

Abstract

The methanol extract of Erythrina variegata (Leguminosae) stem bark showed significant anti-cancer activity against breast cancer T47D cell-lines in vitro using the Sulforhodamine B (SRB) assay and anti-malarial activity against Plasmodium falciparum in vitro using the lactate dehydrogenase (LDH) assay. By using the anti-cancer and anti-malarial activity to follow the separations, the methanol extract was separated by combination of column chromatography. The chemical structure of an anti-cancer and an anti-malarial compound was determined on the basis of spectroscopic evidence and comparison with the previously reported and identified as an erystagallin-A. The erystagallin-A showed anti-cancer activity against breast cancer T47D cell-lines in vitro used with IC50 3.3 μg/mL and anti-malarial activity against both strains of parasite in vitro used with IC50 of 0.02 μg/mL against 3D7 and 6.0μg/mL against K1, respectively. These results strongly suggested that stem bark of E. variegata is a promising sources for anti-cancer and anti-malarial agents.

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Keywords

Anti-cancer, anti-malarial, erystagallin-A, Erythrina variegata.

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