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Medico-Legal Update - An International Journal
Year : 2011, Volume : 11, Issue : 1

Print ISSN : 0971-720X. Online ISSN : 0973-5672.

Comparative studies of some toxic ions like Pb2+ & Cd2+ on the reproductive functions in female rats: A case study

Dhir Vaneet, Assistant Professor

Sikh National College (NAAC, B+), Qadian 143516, Punjab, India.

Abstract

In my previous work1–2 I (Dhir) worked on the physicochemical interactions in between the biomolecules (eccrine) with series of cations and also studied the importance of hydrophobic character of big biomolecules. Therefore; in this pilot project I (Dhir) studied the effect of toxic cations like Pb2+ & Cd2+ on the various biological aspects. Heavy metal toxicity is a serious worldwide problem which adversely affects the growth, health, reproductive performance and life span of all living organisms. Leads (lead acetate) and cadmium(cadmium sulphate) being a toxic cumulative poison and an environmental pollutant, experiments were conducted at an oral chronic dose of (60 mg/kg/day) for 90 days on adult female rats (Rattus Norvegicus) and its effect on the reproductive functions in relation to the biochemical effects was studied. It was observed that the chronic dose of lead caused an elevation in the level of proteins, acid phosphatase, alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase in all the soft tissues studied indicating tissue damage, whereas it was observed be me (Dhir) the effects were more severe in case of cadmium. However no literature was available so far as to compare the toxicity level of cadmium with lead (because the cadmium ions or compounds are available in trace amount but I (Dhir) cannot rule out the possibility of cadmium pollution). Therefore it is necessary to compare lead with cadmium. Cadmium also inhibited the level of acetylcholinesterase in all the tissues. Fertility tests by pairing treated females with males showed that lead and cadmium treated female showed irregular oestrous cycle and the fertility rate dropped to 40%(in case of lead) and 50% (in case of cadmium) as female pups of lead treated mothers showed loss in weight, high mortality rate, poor growth rate and late vaginal opening. Histological studies of ovary showed atresia (figures-5-8) in all the stages of folliculogenesis sustaining the poor fertility observations. It was also observed by me (Dhir) that there must be some relation in terms of anionic part of salt is being considered because I (Dhir) have taken lead in the form of acetate(because acetate are available in solution easily to feed the rats) while cadmium in the form of sulphate.

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