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Year : 2015, Volume : 4, Issue : 3
First page : ( 131) Last page : ( 142)
Print ISSN : 2319-118X. Online ISSN : 2319-1198. Published online : 2015 December 1.
Article DOI : 10.5958/2319-1198.2015.00019.6

Past and Present Therapeutics for Alzheimer's Disease

Seth Sonakshi1,*, Kakkar Vandita2

1Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India

2Institute of Pharmaceutical Sciences, Punjab University, Chandigarh, Punjab, India

* Corresponding author Email id: sonakshi.pharma@gmail.com

Abstract

Alzheimer's disease is a progressive, degenerative disorder that attacks the brain's nerve cells, or neurons, resulting in loss of memory, thinking and language skills, and behavioural changes. Alzheimer's disease is the most common cause of dementia, or loss of intellectual function, among people aged 65 and older. Two types of abnormal lesions clog the brains of individuals with Alzheimer's disease: Beta-amyloid plaques-sticky clumps of protein fragments and cellular material that form outside and around neurons; and neurofibrillary tangles-insoluble twisted fibers composed largely of the protein tau that build up inside nerve cells. Several molecular biomarkers are recognised to be associated with the pathology of AD. However, the currently available laboratory methods are not sensitive enough for such an early diagnosis. Nanotechnology offers a number of highly sensitive molecular detection tools that may make this goal achievable. These nanodiagnostic tools utilise different nanoparticles/nanostructures, statins and are based on different physicochemical interactions that may be utilised either in vitro or in vivo.

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Keywords

AD: Alzheimer's disease, NFTs: neurofibrillary tangles, Aβ: Amyloid beta, APP: amyloid precursor protein, CSF: Cerebrospinal fluid, DNA: Deoxyribonucleic acid, EMEA: Evaluation of Medicinal.

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